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ORIGINAL ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 4  |  Page : 235-238

Importance of assessment of microalbuminuria in β-thalassemia major patients


1 Department of Biochemistry, JSS Medical College, JSS University, Mysore, India
2 Department of Paediatrics, JSS Medical College, JSS University, Mysore, India

Correspondence Address:
Parveen Doddamani
House no 286, Near Government Primary School, Shivanand Nagar, Navanagar, Hubli - 25, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.107864

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Introduction: β-thalassemia major is one of the most common hereditary hematologic disorders characterized by severely impaired β-globulin synthesis. Renal proximal tubular dysfunction may occur in children with β-thalassemia major without clinical manifestations of renal dysfunction or decrease in GFR. However, there is paucity of information about renal involvement in this disease and its early detection in patients with β-thalassemia major is rare. Aims and Objectives: The aim of the present study was to determine the levels of urinary microalbumin along with serum levels of urea, creatinine, uric acid, calcium and inorganic phosphate and to correlate the levels of urinary microalbumin with the above parameters in β-thalassemia major patients. Results: Serum urea, uric acid and phosphate increased ( P < 0.001, <0.05, <0.001 respectively) while serum calcium was decreased ( P < 0.001) in patients with β-thalassemia major patients when compared to healthy controls. Microalbuminuria ( P < 0.001) was seen in patients with β-thalassemia major patients indicating renal damage. Conclusion: Our study emphasizes the need to include microalbuminuria levels into the routine follow up of these patients. Thereby, impedance of disease progress will improve the patients' quality of life.


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