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Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 40-43

Insulin sensitivity and skeletal muscle function in adult men with type II diabetes mellitus

Department of Physiology, Sapthagiri Institute of Medical Sciences, Bengaluru, Karnataka, India

Correspondence Address:
N Roopashree
Department of Physiology, Sapthagiri Institute of Medical Sciences, Hesaraghatta Main Road, Bengaluru, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.130611

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Background: Insulin resistance (IR) is an important component in the pathogenesis of type II diabetes. As skeletal muscle is known to be the key site for glucose disposal, any physiological or structural alterations might lead to IR. Aim: Assessment of insulin sensitivity and skeletal muscle function in diabetic men. Materials and Methods: A total of 30 diabetic men were matched with 30 controls. Static and dynamic endurance for muscle function and insulin sensitivity was calculated by homeostatic model assessment. Results: Diabetic men showed early onset of fatigue (P < 0.05) and faster decline of muscle strength for static endurance (P < 0.05) even though muscle mass (MM) was comparable to controls. They had a decreased beta cell function, increased IR and decreased sensitivity. Conclusions: As the diabetic men are prone for skeletal muscle dysfunction, they have to adopt preventive strategies including resistance-training exercise program to improve skeletal muscle function. Skeletal muscle being one of the key sites for glucose disposal, improving the skeletal muscle function will in turn help in improving the insulin sensitivity.

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