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Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 60-62

Kikuchi-Fujimoto disease: A rare cause of generalized lymphadenopathy

Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, Wardha, India

Correspondence Address:
Sachin R Agrawal
Department of Internal Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442 001, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.130620

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Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare benign condition of uncertain etiology mainly seen in young females. Although the disease presents most commonly as cervical lymphadenopathy and fever, it may rarely present as generalized lymphadenopathy. A 14-year-old female patient presented with multiple progressive swellings in the neck. On evaluation, she was found to have generalized lymphadenopathy. Histopathological examination of cervical lymph node confirmed the diagnosis of KFD. Paracortical area of coagulative necrosis with abundant karyorrhetic debris surrounded by various types of histiocytes at the periphery is the characteristic histological features of the disease. KFD is a rare benign self-limited disease of lymph node with resolution of signs and symptoms in 1-4 months. Differential diagnosis of KFD should be kept in mind in patients presenting with generalized lymphadenopathy since it may be misdiagnosed as more serious pathology like lymphoma.

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