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Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 66-69

Simple, non-invasive and cost-effective method for detection of Chlamydia trachomatis infection (a silent, sexually transmitted pathogen that can cause infertility)

Department of Microbiology, Sri Aurobindo Institute of Medical Sciences Medical College and PG Institute, Indore, Madhya Pradesh, India

Correspondence Address:
Trupti Bajpai
Department of Microbiology, Sri Aurobindo Institute of Medical Sciences Medical College, MR 10 Crossing, Indore Ujjain Road, Indore, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.130623

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Background: Chlamydia trachomatis (C. trachomatis), an obligate intra-cellular bacterial pathogen has been recognized as one of the major cause of sexually transmitted infections throughout the world. Being asymptomatic, these infections have severe ramifications for the reproductive health of women leading to the long term complications like infertility. Screening women for C. trachomatis is highly desirable in developing countries. Aims: To determine the prevalence of Chlamydia trachomatis infection in infertile women attending In vitro fertility (IVF) centers. Also to highlight the importance of non-invasive serological diagnostic tool for screening infertile women to rule out Chlamydia as one the causes of infertility. Materials and Methods: The present study was carried out in the Microbiology section of Central Laboratory of a tertiary care hospital from Sep. 2012 to August 2013. Serum samples from 128 suspected women patients were diagnosed by C. trachomatis IgG ELISA (Calbiotech). Positive and borderline positive samples were retested after one month of initial testing by the same method. Results: Out of 128 serum samples tested, six (4.68%) samples were found to be positive for C.trachomatis IgG while seven (5.46%) samples were borderline positive. Paired sera-analysis finally confirmed 8.59% sero-positivity. Conclusion: IgG antibody detection is an effective and non-invasive tool for the detection of Chlamydia and more viable option than other techniques in India. Screening of women with secondary infection for C. trachomatis is strongly recommended to allow early therapeutic interventions. Since, a significant proportion of women expressed the evidence of exposure to C.trachomatis in our study; this cannot be ignored as one of the probable cause of infertility in women.

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