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SHORT COMMUNICATION
Year : 2015  |  Volume : 4  |  Issue : 2  |  Page : 115-118

Correlation between homocysteine and Vitamin B12 levels: A post-hoc analysis from North-West India


1 Department of Community Medicine, Dr. RP Government Medical College, Tanda, Himachal Pradesh, India
2 Department of Biochemistry, Dr. RP Government Medical College, Tanda, Himachal Pradesh, India
3 Department of Pathology, Dr. RP Government Medical College, Tanda, Himachal Pradesh, India

Correspondence Address:
Sunil Kumar Raina
Department of Community Medicine, Dr. RP Government Medical College, Tanda, Himachal Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.154915

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Background: Homocysteine has been shown to be a risk factor for cardiovascular disease and is a degradation product of sulfur containing amino acids. The aim of this post-hoc analysis was aimed at arriving at homocysteine levels among voluntarily consenting healthy adults in the context of other hematological parameters. Methods: The data for this post-hoc analysis were derived from an observational study carried out at a medical college in rural North-west India. Results: About 77.42% of those participants enrolled in this study having serum homocysteine level more than 30 μmol/L were seen to possess suboptimal serum Vitamin B 12 (<200 pg/ml). On subjecting data to regression analysis, serum homocysteine was observed to possess an inverse correlation with serum level of Vitamin B 12, in general. Conclusions: Hyperhomocysteinemia observed in our study was sufficiently common and wholly ascribable to low Vitamin B 12 concentration as we did not find any case of subnormal serum folic acid level.


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