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ORIGINAL ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 2  |  Page : 73-78

Antihyperlipidemic activity of Hibiscus rosa-sinensis Linn. ethanolic extract fractions


1 Department of Pharmacognosy and Phytochemistry, K.L.E University's College of Pharmacy, Belgaum, Karnataka, India; Unit of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Semeling, Kedah Darul Aman, Malaysia
2 Department of Pharmacognosy and Phytochemistry, K.L.E University's College of Pharmacy, Belgaum, Karnataka, India

Correspondence Address:
Mukesh Singh Sikarwar
Unit of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.153618

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Aim: The study investigates the antihyperlipidemic effect of Hibiscus rosa-sinensis Linn. (Malvaceae) ethanolic extract fractions in triton and atherogenic diet-induced hyperlipidemic rats. Materials and Methods: Oral administrations of 500 mg/kg body weight of various fractions of selected plant were evaluated for possible antihyperlipidemic activity in triton and atherogenic diet-induced hyperlipidemic rats for duration of 48 h and 14 days respectively. In triton model, hyperlipidemia was induced by intra-peritoneal injection of a saline solution of triton 400 mg/kg in rats, whereas in diet induced model, rats were made hyperlipidemic by giving atherogenic diet for 20 days using oral route of administration. A comparative assessment was also made between the actions of selected drug with simvastatin, known antihyperlipidemic drug. Result and Discussion: The outcomes of this study were expressed as mean ± standard error and data were evaluated by using analysis of variance followed by Dunnett's t-test for multiple comparisons. Oral administration of 500 mg/kg body weight of ethanolic extract residual fraction of Hibiscus rosa-sinensis Linn. flowers exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Conclusion: Our results demonstrated that ethanolic extract fraction of Hibiscus rosa-sinensis Linn. possessed significant antihyperlipidemic activity.


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