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Year : 2016  |  Volume : 5  |  Issue : 3  |  Page : 143-147

Oral clonidine for shivering prophylaxis in patients undergoing elective urological surgeries under subarachnoid anesthesia

Department of Anaesthesia, Dr. D Y Patil Medical College, Pimpri, Pune, Maharashtra, India

Correspondence Address:
Dr. Aparna Bagle
Department of Anaesthesia, Dr. D Y Patil Medical College, Pimpri, Pune - 411 018, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.187798

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Background and Aim: Perioperative shivering during subarachnoid anesthesia is a common complication in patients undergoing urological procedures. It is secondary to peripheral vasodilatation from sympathetic blockade and/or cold irrigating fluids. Previous studies mainly emphasized on treating shivering rather than preventing it. Therefore, our aim was to evaluate the prophylactic efficacy of the oral formulation of clonidine for prevention of perioperative shivering in patients undergoing urological procedures under subarachnoid anesthesia and also to evaluate any side effects associated with it. Materials and Methods: A total of 60 patients scheduled for elective urological surgeries under subarachnoid blockade were enrolled into this prospective, randomized, double-blind controlled study. Patients were randomly assigned to two groups. Group C (n = 30) received oral clonidine 0.1 mg tablets, whereas Group P (n = 30) received folic acid 5 mg (placebo) tablets 90 min before surgery. Subarachnoid blockade was administered with heavy bupivacaine (0.5%), 3 ml (15 mg). All procedures were performed in the similar operation theater conditions. Hemodynamic parameters, axillary temperature, and shivering were recorded. Any side effects were recorded and treated appropriately. P <0.05 was considered statistically significant. Results: Incidence of shivering was significantly less in Group C (10%) when compared with that of the Group P (40%) (P < 0.01). Patients in Group C had Grade 1 or 2 shivering while in the Group P patients experienced various grades of shivering ranging from Grades 1 to 4. Conclusion: Incidence and severity of perioperative shivering was significantly less (P < 0.05) in clonidine group without significant side effects.

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