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Year : 2016  |  Volume : 5  |  Issue : 4  |  Page : 263-266

The effects of ocimum sanctum aqueous extract on intestinal motility of wistar albino rats by in vitro study

1 Department of Physiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, Tamil Nadu, India
2 Department of Physiology, Dr. ALM PG IBMS Campus, University of Madras, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. K Maheshkumar
Department of Physiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.194130

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Introduction: Ocimum sanctum has been in use for thousands of years because of its diverse healing property in various conditions. Hence, to evaluate its effect on intestinal motility, the present study aimed to find the effects of O. sanctum on intestinal motility of Wistar albino rats by in vitro study. Materials and Methods: Aqueous extract of O. sanctum was prepared from mature leaves, and from this stock solution, various dilutions of 1:10,000, 1:1000, 1:100, and 1:10 were prepared and used. Thirty healthy adult Wistar-stained male albino rats were selected and divided into five groups (each group comprises six animals): control, 1:10,000, 1:1000, 1:100, and 1:10 dilution groups. Intestinal segments 2-3 cm below the duodenum was removed from the intestinal segment and mounted in the Dales Organ Bath with Tyrode's solution and respective contraction responses for the various dilutions were recorded separately in the physiograph. Results: O. sanctum aqueous extract showed that the amplitude and force of contractions in various dilutions have increased when compared to the control group in the intestinal motility. Among the various dilutions, 1:100 dilution group showed significant (P < 0.01) difference in the contraction than the other dilutions. Conclusion: The increase of amplitude with an increase in duration indicates that O. sanctum could slow down the intestinal motility. This reveals that the aqueous extract of O. sanctum contains pharmacologically active substances with antidiarrheal properties.

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