TY - JOUR A1 - Santra, Ranjita A1 - Chaudhuri, Patralekha T1 - Rosuvastatin induced periorbital tremor in a case of familial hypercholesterolemia Y1 - 2015/7/1 JF - International Journal of Health & Allied Sciences JO - Int J Health Allied Sci SP - 171 EP - 173 VL - 4 IS - 3 UR - https://www.ijhas.in/article.asp?issn=2278-344X;year=2015;volume=4;issue=3;spage=171;epage=173;aulast=Santra DO - 10.4103/2278-344X.160893 N2 - Rosuvastatin is an anti-lipaemic drug belonging to the class of statins that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Cholesterol lowering agent myopathy (CLAM) is well recognized among physicians and patients. Less well known are the small number of patients on statins who have shown signs of peripheral neuropathy, either in addition to or separately from CLAM. Here we report a case of a 45-year-old lady who stared experiencing periorbital tremors shortly after introduction of rosuvastatin. While the pathophysiology of statin-induced myopathy remains unclear, we hope that this case will encourage others to report similar symptomatology, perhaps enabling to gain more insight on the cases of iatrogenic myopathies. Hence, pharmacogenetics study may prove to be useful for personalized therapy. ER -