TY - JOUR A1 - Jawarkar, Ajay A1 - Lokare, Pushpa A1 - Kizhatil, Anuradha A1 - Jawarkar, Jyoti A1 - Kale, Sandhya T1 - Study on effectiveness and outcome of mifepristone and misoprostol in medical termination of pregnancy Y1 - 2017/1/1 JF - International Journal of Health & Allied Sciences JO - Int J Health Allied Sci SP - 35 EP - 38 VL - 6 IS - 1 UR - https://www.ijhas.in/article.asp?issn=2278-344X;year=2017;volume=6;issue=1;spage=35;epage=38;aulast=Jawarkar DO - 10.4103/2278-344X.200200 N2 - BACKGROUND: One of the most effective and safest medical abortion (MA) regimens consist of the use of a combination of mifepristone and misoprostol. Misoprostol can be administrated by oral or vaginal route after giving a single dose of mifepristone. The present study was conducted to assess the effectiveness and complications by these two routes. SUBJECTS AND METHODS: The present study was nonrandomized clinical trial conducted at two private hospitals and medical college, Amravati city. The women having a history of amenorrhea ≤49 days and who were willing for medical termination of pregnancy by MA pills method were included in the study during the 1-year after obtaining ethical approval. The women in both groups were given tablet mifepristone (200 mg day) on day 1 orally followed by tablet misoprostol (two tablets of 200 μg) on day 3 orally in one group and vaginally in other group. RESULTS: The success rate of medical termination in group with oral administration of misoprostol was 96.3% as compared to 97.7% success rate in group with vaginal administration of misoprostol. The gastrointestinal side effects were 41.4% in group with oral administration of misoprostol as compared to 21.7% in group with vaginal administration of misoprostol. The Chi-square test of significance was applied using SPSS software version 16.0. CONCLUSIONS: The success of medical termination of pregnancy was comparable in both groups with slightly higher success rate by vaginal route of administration of misoprostol. ER -